Cards (39/43)

 

O – THE FOOL

“Where your journey begins”
• Teleports the player to the first room of the current floor.

I – THE MAGICIAN

“May you never miss your goal”
• For the current room, tears now have the Spoon Bender effect, which allows them to curve towards enemies and gives them a purрle appearance.

II – THE HIGH PRIESTESS

“Mother is watching you”
• Summons Mom’s foot which will stomp on a random enemy in the current room, dealing 300 damage.
• If no enemies are in the current room, the foot will target Isaac (and do damage if it hits), however it can be used to break rocks.

III – THE EMPRESS

“May your rage bring power”
• Gives the player the ♥♥♥♥♥ of Babylon effect for the current room, increasing damage and speed.

IV – THE EMPEROR

“Challenge me!”
• Teleports the player to the Boss room on the current floor.

V – THE HIEROPHANT

“Two prayers for the lost”
• Spawns 2 Soul hearts on the floor.

VI – THE LOVERS

“May you prosper and be in good health”
• Spawns 2 red hearts on the floor.

VII – THE CHARIOT

“May nothing stand before you”
• Grants the same effect as ‘My Little Unicorn’, which makes Isaac invincible and deal 40 contact damage to enemies per hit.

VIII – JUSTICE

“May your future become balanced”
• Spawns 1 bomb, 1 key, 1 coin, 1 heart, which can be random variants of each.

IX – THE HERMIT

“May you see what life has to offer”
• Teleports the player to the Shop.
• On or below the Womb, this acts as a random teleport, since there are no shops on those floors.

X – WHEEL OF FORTUNE

“Spin the wheel of destiny”
• Spawns a Slot Machine or a Fortune Machine.

XI – STRENGTH

“May your power bring rage”
• Gives the player the Magic Mushroom effect, which increasing size and all stats by 1 for the current room.
• If you use the Strength card with 12 heart containers, it will take you down to 11 when you leave the room.

XII – THE HANGED MAN

“May you find enlightenment”
• Gives the player the flying effect for the current room, allowing the player to fly over obstacles in the room.
• This card is useless if you have any item which allows you to permanently fly.

XIII – DEATH

“Lay waste to all that oppose you”
• Deals 40 damage to all enemies in the room in a similar style to the Necronomicon.

XIV – TEMPERANCE

“May you be pure in heart”
• Spawns a Blood Donation Machine.

XV – THE DEVIL

“Revel in the power of your darkness”
• Gives the Book of Belial effect for the current room, increasing damage.

XVI – THE TOWER

“Destruction brings creation”
• Spawns some troll bombs at random locations in the current room.
• Each bomb deals 60 damage (normal bomb damage.

XVII – THE STARS

“May you find what you desire”
• Teleports the player to the Item Room.
• On or below the Womb, this acts as a random teleport, since there are no item rooms on those floors.

XVIII – THE MOON

“May you find all you have lost”
• Teleports the player to the Secret Room.

XIX – THE SUN

“May the light heal and enlighten you”
• A card with three uses: A full heal, deals 100 damage to all enemies in the current room and reveals the entire map for the current floor (Treasure Map + The Compass).

XX – JUDGEMENT

“Judge lest ye be judged”
• Spawns a beggar.
• Has a chance to be a demon beggar.
• Killing a Devil Beggar, Key Master, or Shell Game Beggar gives you an increased chance of finding Angel rooms instead of Devil rooms. See the dedicated Devil room page for more details.

XXI – THE WORLD

“Open your eyes and see”
• Reveals the entire map and shows the icons for every room which has one.
• This is completely useless if you currently have both the Treasure Map and The Compass.

2 OF SPADES

“Item multiplier”
• Doubles the number of keys you have.
• If you have no keys, it gives you two.

2 OF CLUBS

“Item multiplier”
• Doubles the number of Bombs you have.
• If you have no bombs, it gives you two.

2 OF HEARTS

“Item multiplier”
• Doubles your current red hearts up to full health.
• This card is useless for the Bluе Baby.

2 OF DIAMONDS

“Item multiplier”
• Doubles the number of coins you have.
• If you have no coins, it gives you two.

THE JOKER

“???”
• Teleports you to the Devil Deal Room on the current floor.

CHAOS CARD

“???”
• A card which can be thrown as a projectile directly infront of Isaac, instantly killing anything it hits, including most bosses.
• If thrown at a multi-phase boss with multiple forms such Satan, Mega Satan or Hush it will only kill that particular phase of the boss.
• If thrown at a multi-phase boss that works from a single health bar such as Isaac, ??? or The Lamb, it will die instantly.
• Will destroy rocks and poop in its path.
• Can also be thrown against a door to open it (Doesn’t work against Mega Satan’s door).
UNLOCK: Unlock this card by beating Challenge #9 (Demo Man).

CREDIT CARD

“Charge it!”
• When used, removes the price tag from all items in the current shop or devil deal, making everything free.
• The effect of the Credit Card only lasts for the current room.
UNLOCK: Unlock this card by beating Challenge #10 (Cursed!).

RULES CARD

“???”
• Displays a random cryptic message on the screen similar to the fortune machine ones. One of the following messages may show:
• “Rooms may yield more than you expect”
• “Some doors require a blessing. Carry them with you”
• “The walls will harden over time. Time is the essence”
• “Sleeping gatekeepers will need to be awoken with a loud sound”
• “A piece of paper is your guide”
• “Deny his gifts to attain your reward”
• “A dark market lies under your feet
• “Chub dislikes smoke!
UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon).

CARD AGAINST HUMANITY

“Something stinks…”
• When used, fills the entire room with poop!
UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons).

SUICIDE KING

“A true ending?”
• When used, instantly kills you and spawns 10 pickup on the floor.
• Each of the 10 things spawned can be any type of consumable or sometimes a pedestal item (up to a maximum of 3 pedestal items).
• Any pedestal item created by Suicide King will be related to the room where it was used, meaning that using it in the Angel room will spawn Angel room items.
UNLOCK: Unlock this card by beating Challenge #7 (Suicide King).

GET OUT OF JAIL FREE CARD

“Open sesame”
• When used, will open all doors in the current room, similar to a one-time use of Dad’s Key.
UNLOCK: Unlock this card by beating Challenge #22 (Speed).

? CARD

“Double active”
• When used this card will activate a use of your spacebar item for free.

ACE OF HEARTS

“Convert all”
• When used, turns all pickups and chests in the room into Hearts.
UNLOCK: Unlock this item by defeating any floor after Basement I with only half a heart of health (works as The Lost).

ACE OF SPADES

“Convert all”
• When used, turns all pickups and chests in the room into Keys.
UNLOCK: Unlock this item by defeating The Lamb without taking hearts, coins and bombs.

ACE OF CLUBS

“Convert all”
• When used, turns all pickups and chests in the room into Bombs.
UNLOCK: Unlock this item by getting a 3 win streak.

ACE OF DIAMONDS

“Convert all”
• When used, turns all pickups and chests in the room into Coins.
UNLOCK: Unlock this item by defeating The Lamb in under 20 minutes.

HOLY CARD

“You feel protected”
• Grants the Holy Mantle effect for one room, which will negate your next hit of damage
UNLOCK: Unlock this item by defeating Delirium in The Void floor with The Lost.

Cards (43/43)

 

EMERGENCY CONTACT

“Help from above”
• When used will cause two of Mom’s Hand to come down and grab a random enemy.

HUGE GROWTH

“Become immense!”
• Temporarily makes Isaac huge, giving him +7 Damage Up and +30 Range Up for the rest of the current room
• Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Coper140
UNLOCK: Unlock this item by getting 5 items or consumables that increase your size, e.g. ‘One Makes you Larger’ pills, Magic Mushroom etc.

ANCIENT RECALL

“Draw 3 cards”
• Spawns 3 random cards on the floor when used
• Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Coper140

ERA WALK

“Savor the moment”
• When used, this card will slow down enemies, Isaac’s tears by -1 Shot Speed, but speed up Isaac’s movement speed by +0.50 for the rest of the current room
• Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Coper140
UNLOCK: Unlock this item by getting both the Broken Watch and the Stop Watch in your collection

Runes (10/10)

 

RUNE OF ALGIZ

“Resistance”
• When used, gives you an invincibility effect which lasts for 30 seconds (much longer than normal invincibility effects).
UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue).

RUNE OF ANSUZ

“Vision”
• When used, reveals the entire map including all the secret room locations and other icon rooms.
UNLOCK: Unlock this card by beating Challenge #5 (The Tank).

RUNE OF BERKANO

“Companionship”
• Summons 3 blue friendly spiders and 3 blue flies.
UNLOCK: Unlock this card by beating Challenge #20 (Purist).

RUNE OF DAGAZ

“Purity”
• Removes the curse which is in effect on the current floor.
• Can also cure the effect of the Amnesia pill.
• +1 Soul Heart.
UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls).

RUNE OF EHWAZ

“Passage”
• Creates a trapdoor on the floor (Same effect as We Need To Go Deeper).
UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma).

RUNE OF HAGALAZ

“Destruction”
• When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances.
UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black).

RUNE OF JERA

“Abundance”
• When used this rune will double all pickups on the floor in the room.
• Creates copies of pickups, even if you haven’t purchased them yet.
• Can be used to double the number of golden item chests in the first room of the final Chest floor.
UNLOCK: Unlock this card by beating Challenge #2 (High Brow).

RUNE OF PERTHRO

“Change”
• Rerolls all pedestal items in the current room (One time use of the D6).
UNLOCK: Unlock this card by beating Challenge #6 (Solar System).

BLANK RUNE

“???”
• When used, gives a random Mystic rune effect.
• Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro.
• Also has a 25% chance to spawn another Blank Rune upon use.
UNLOCK: Unlock this card by beating Challenge #30 (Guardian).

BLACK RUNE

“Void”
• When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed.
• Also consumes all pickups in the room and turns them into blue flies and spiders.
UNLOCK: Unlock this item by beating Greedier mode as Apollyon.

No real category (5/5)

 

DICE SHARD

• Gives a one-time use of the D6 and D20 effects at the same time.

GOLD KEY

• Once picked up, you gain unlimited key use for the rest of the floor.

GOLD HEART

• Once picked up, the gold heart will drop money on the floor the next time Isaac loses a heart.
UNLOCK: Unlock this item by beating challenge #21 (XXXXXXXXL).

BONE HEART

• Takes three hits to deplete and can be refilled with red hearts, but disappears forever when depleted
UNLOCK: Unlock this item by unlocking the Forgotten character.

GOLD BOMB

• Once picked up, you gain unlimited bomb use for the rest of the floor.
UNLOCK: Unlock this item by beating challenge #23 (Blue Bomber).

Rebirth Pills (28/28)

 

48 Hour Energy

• Fully recharges your active item and drops 1-2 battery pickups. Can be used with Placebo to generate infinite batteries

Amnesia

• Hides the floor map for the rest of the current floor (same as curse of the lost). Can be negated with Black Candle

Bad Gas

• Isaac farts, poisoning enemies around him

Bad Trip

• Deals damage to yourself

Balls of Steel

• +2 Soul Hearts

Bombs are key

• Switches number of bombs and keys

Explosive Diarrhea

• Spawns five live troll bombs behind Isaac, one per second

Full Health

• Restores all your empty red heart containers

Health Down

• -1 HP. If you have 1 or less heart containers, this pill becomes Health Up

Health Up

• +1 HP

Hematemesis

• Empties all but one red heart container and spawns 1-4 red hearts on the floor

I can see forever

• Opens secret room and super secret room entrances on the current floor

I found pills

• Changes the appearance of Isaac’s face for the current room (Cosmetic change only)

Lemon Party

• Spawns a large yellow pool on the floor around you, damaging enemies which walk in it

Luck Down

• Reduces your luck stat by -1

Luck Up

• Increases your luck stat by +1

Paralysis

•Prevents you from moving for a short while

Pheromones

•Applies the charm effect to all enemies in the room for a short while

Puberty

•Causes Isaac to grow hair for the rest of the run. Cosmetic change only. In Afterbirth+, taking 3 of this pill gives the Adult transformation

Pretty Fly

•Gives Isaac +1 fly orbital, which blocks enemy projectiles and damages fly-type enemies on touch

Range Down

•Reduces your range stat by -2

Range Up

•Increases your range stat by +2.5

R U a wizard?

•Tears will shoot diagonally for about 60 seconds. Effect persists between rooms while the time period is active

Speed Down

•Reduces your speed stat by -0.12

Speed Up

•Increases your speed stat by +0.15

Tears Down

•Reduces your tears stat by -0.28

Tears Up

•Increases your tears stat by 0.35

Telepills

•Teleports you to a random room when used. Has a small chance to take you to the I AM ERROR room, and a smaller chance to teleport to a Black Market

Afterbirth Pills (11/11)

 

Addicted

• Causes you to take a full heart of damage for all sources for the current room. Unlocked from Challenge #24 – PAY TO PLAY

Friends till the end

• Spawns three friendly blue attack flies

Infested!

• Destroys all poops in the room and spawns a blue attack spider on every destroyed poop

Infested?

• Spawns one blue attack spider for every enemy in the room. If there are no enemies this pill spawns 1-3 blue spiders instead

One makes you smaller

• Reduces Isaac’s size and hitbox size

One makes you larger

• Increases Isaac’s size, but does not affect the size of his hitbox

Percs

• Causes Isaac to only take half a heart of damage from all sources for the current room (The Wafer effect). Unlocked from Challenge #24 – PAY TO PLAY

Power Pill

• Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect)

Re-Lax

• Causes Isaac to spawn poops behind him while he walks for a few seconds. Similar to Explosive Diarrhea but with poop

Retro Vision

• Pixelates the screen for a few seconds, obscuring your vision. Happens a total of 3 times over 30 seconds

???

• Gives the curse of the maze effect for the current floor. Unlocked from Challenge #25 – Have a Heart

Afterbirth+ Pills (8/8)

 

Feels like I’m walking on sunshine!

• Turns Isaac invincible for a few seconds (similar to Unicorn Stump). Unlocked from the ‘Sin Collector’ achievement (collect every Bestiary entry)

Gulp!

• When used will consume your current trinket, destroying it and giving you its effect permanently. Unlocked from the ‘Once more with the feeling!’ achievement (complete a victory lap, defeating the lamb boss)

Horf!

• When used, shoots an Ipecac explosive shot. Unlocked from the ‘Dedication’ achievement (participate in 31 dailies in a row)

I’m Drowsy…

• Slows all enemies for the rest of the current room

I’m excited!!!

• Speeds up all enemies for the rest of the room. The effect triggers again 30 seconds after use and again 60 seconds after use

Something’s wrong…

• Spawns a pool of black creep beneath Isaac

Vurp!

• Spawns the last pill you used. Spawns another Vurp! pill if no other pills were used yet. Unlocked from the ‘U broke it!’ achievement (collect 50 items in a single run)

X-Lax

• Spawns a pool of slippery brown creep beneath Isaac

Dice Rooms

 

1 Dot

• Rerolls all of your items. (Does not change your trinkets, pills or cards)

2 Dot

• Rerolls all pickups in the room. (D20 effect)

3 Dot

• Rerolls all pickups on the entire floor.

4 Dot

• Rerolls all pedestal items on the floor. (Does not roll your devil deal items)

5 Dot

• Reroll and restart the current floor (Forget Me Now effect).

6 Dot

• Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 + 4 rooms).

I hope you enjoy the Guide we share about The Binding of Isaac: Rebirth – Every consumable + misc in Rebirth/AB/AB+/Repentance + Dice Rooms; if you think we forget to add or we should add more information, please let us know via commenting below! See you soon!